High-Fat Diet: Gut Health, Immunity, and Inflammation

Saturated vs. Unsaturated Fats & Immunity

Saturated fats are processed through a pathway called fat oxidation, which hinders immune function, while unsaturated fats like oleic acid form safety lipid beads in the cells, assisting to maintain appropriate immune feedbacks.

“The more hydrogenated fats we consume, the more swelling that builds up,” said research study writer Cyril Seillet from The Walter and Eliza Hall Institute of Medical Research in Australia. “This swelling accumulation is originally quiet, continuing to be hidden in our bodies until years later on, where it can present as persistent inflammation.”

Rapid Gut Microbiome Changes

Even more, within a week on the high-fat diet plan, the intestine microbiome had actually quickly changed, displaying a decrease in advantageous microorganisms that produce short-chain fats and a spreading of harmful bacteria.

Conversely, these results offer to clarify why diet regimens abundant in olive oil and unsaturated fats, such as the admired Mediterranean diet regimen, are connected with lower levels of inflammation and enhanced digestive tract health.

High-Fat Diet Impairs Immune Cells

After just two days on high-fat diet plans, scientists observed that particular subtypes of ILC3 immune cells currently showed lowered IL-22 production. A week into the high-fat diet regimen, all ILC3 subtypes were compromised.

Using specific devices, the research group discerned that one week on a high-fat diet correlated to “leakier” mice intestinal tracts, a permeability that allowed extra possibly hazardous materials to go through.

To demonstrate exactly how the processing of these fats influences digestive swelling, the research team generated colitis in the computer mice. The mice fed saturated fats revealed higher tissue damage than those that adhered or consumed unsaturated fats to a regular diet plan.

The study team found that after returning to a normal diet, intestine function enhanced after simply 2 days and returned to regular after seven days. This quick improvement recommends dietary interventions can rapidly bring back gut health and wellness.

The high-fat diet led to the rapid suppression of specific immune cells called ILC3s, which generate a safety compound called interleukin-22 (IL-22). This suppression is disastrous for the digestive system.

Diet’s Impact on Gut Barrier

New study confirms that simply two days of consuming a high-fat diet can compromise vital immune cells in the gut and deteriorate the digestive barrier, suggesting the effect of our everyday dietary options is much more immediate than previously thought.